Alpha-Ketoglutarate, the Metabolite that Regulates Aging in Mice
WEBSep 9, 2020 · Starting at 18 months of age, male and female mice were fed regular mouse chow supplemented with calcium aKG. The authors report a significant survival benefit in the aKG-treated mice that was somewhat sexually dimorphic.
Alpha-ketoglutarate as a potent regulator for lifespan and …
WEBMay 1, 2023 · Importantly, AKG can improve bone mineral density in human and animal models. Recently it has been shown that the treatment of 18-month-old mice with AKG increased bone mass, diminished age-related bone loss, and induced osteogenic differentiation (Wang et al., 2020).
Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan …
WEBSep 1, 2020 · Alpha-ketoglutarate is a key metabolite in the tricarboxylic acid (TCA) cycle, and its levels change upon fasting, exercise, and aging. Here, we investigate the effect of alpha-ketoglutarate (delivered in the form of a calcium salt, CaAKG) on healthspan and lifespan in C57BL/6 mice.
Alpha-Ketoglutarate, an Endogenous Metabolite, Extends …
WEBSep 1, 2020 · Dietary-supplemented 2% CaAKG (w/w) increases survival in both cohorts of female mice (Figures 1A and 1B). In the first cohort of females, median lifespan and survival (age at 90 th percentile mortality) were significantly extended by 16.6% and 19.7% from inception of CaAKG feeding.
Bodybuilding supplement promotes healthy aging and extends …
WEBSep 1, 2020 · A dietary supplement bodybuilders use to bulk up may have a more sweeping health benefit: Staving off the ravages of old age. Mice given the substance—alpha-ketoglutarate (AKG)—were healthier as they aged, and females lived longer than mice not on the supplement.
Alpha-Ketoglutarate, the Metabolite that Regulates Aging in Mice
WEBSep 1, 2020 · In this issue of Cell Metabolism, Asadi Shahmirzadi et al. (2020) demonstrate that late-onset dietary supplementation with calcium alpha-ketoglutarate results in increased survival, compressed morbidity, and reduced frailty in mice.
WEBIndependent of sex, aKG treatment decreased the pro-portion of life in which mice were frail, with reduction in frailty scores of 46% for females and 41% for males on the aKG diet. Not surprisingly, the authors showed that that higher frailty scores correlated negatively with …
WEBOur findings demonstrate that AKG, a key metabolite in the TCA cycle, has longevity effects consistent with compressed morbidity in a long-term study of mouse aging. Notably, CaAKG administration started at 18 months of age had robust effects.
Alpha-Ketoglutarate, the Metabolite that Regulates Aging in Mice ...
WEBSep 1, 2020 · In this issue of Cell Metabolism, Asadi Shahmirzadi et al. (2020) demonstrate that late-onset dietary supplementation with calcium alpha-ketoglutarate results in increased survival, compressed morbidity, and reduced frailty in mice. The study provides further evidence for critical links between metabolism, inflammation, and aging. Free full text.
Rejuvant®, a potential life-extending compound formulation with …
WEBNov 11, 2021 · One of the most promising anti-aging compounds discovered to date is Alpha-Ketoglutarate (AKG) . AKG is an endogenous intermediary metabolite in the Krebs cycle whose levels naturally decline during aging. AKG is involved in multiple metabolic and cellular pathways.