α-Ketoglutaric acid ameliorates hyperglycemia in diabetes by …
WEBWe speculated that AKG-induced hyperinsulinemia is the major factor responsible for the glucose-lowering effects of AKG. To test the requirement of insulin, we investigated AKG’s effects in a chemical-induced insulin-deficient T1D mouse model.
Alpha-Ketoglutarate: Physiological Functions and Applications
WEBJan 1, 2016 · Alpha-ketoglutarate (AKG) is a key molecule in the Krebs cycle determining the overall rate of the citric acid cycle of the organism. It is a nitrogen scavenger and a source of glutamate and glutamine that stimulates protein synthesis and inhibits protein degradation in muscles.
Disrupted Alpha-Ketoglutarate Homeostasis: Understanding …
WEBJun 27, 2022 · It has long been discovered that AKG can potentiate insulin secretion. 40 AKG participates in TCA cycle, thus further increasing the ATP/ADP ratio and consequently promoting insulin secretion, especially in a sustained phase, rather than the ATP-sensitive K+ (KATP) channel-mediated acute influence. 41, 42 Intriguingly, it is also recently ...
Alpha-Ketoglutarate dietary supplementation to improve health in …
WEBDec 21, 2021 · It has been hypothesized that AKG mediates the secretion of insulin and human growth hormone, which promotes wound healing . One clinical trial analyzing the effectiveness of AKG on wound healing time in severe burn patients showed that O-AKG (2 × 10 g/day) significantly shortened wound healing time (70 versus 90 days) [ 95 ].
Alpha-ketoglutarate as a potent regulator for lifespan and …
WEBMay 1, 2023 · It has been reported that rapamycin (known as antiaging compound) can cause a diabetic-like condition (called benevolent pseudodiabetes) and insulin resistance, while AKG can play an effective role in glucose homeostasis and ameliorating hyperglycemia in diabetes (Blagosklonny, 2012). It seems that AKG could work as a regulator for metabolic ...
(PDF) α-Ketoglutaric acid ameliorates hyperglycemia in diabetes …
WEBMay 6, 2022 · Previously, we found that α-ketoglutaric acid (AKG) stimulates muscle hypertrophy and fat loss through 2-oxoglutarate receptor 1 (OXGR1). Here, we demonstrated the beneficial effects of AKG...
Alpha-Ketoglutarate dietary supplementation to improve …
WEBAlpha-ketoglutarate (AKG) is an intermediate in the Krebs cycle involved in various metabolic and cellular pathways. As an antioxidant, AKG interferes in nitrogen and ammonia balance, and affects epigenetic and immune regulation.
Potential clinical applications of alpha‑ketoglutaric acid in diseases ...
WEBMar 2, 2022 · Previous study have demonstrated that AKG affects the production of insulin and the development of hyperglycemia, but further experimental evidence is required for the development of clinical treatment options for diabetes.
Nine Amino Acids Are Associated With Decreased Insulin …
WEBMar 18, 2019 · We investigated the association of all twenty AAs with insulin secretion, insulin sensitivity, and fasting and 2-h glucose levels in a large randomly selected population-based METSIM cohort.
Alpha-ketoglutarate partially alleviates effects of high-fat high ...
WEBDec 5, 2023 · Together, our results support AKG-mediated improvement of insulin signaling followed by Nrf2 inhibition in the muscle of HFFD + AKG mice. Insulin resistance in muscles can significantly affect other organs and overall health status of the organism.
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