Metformin use and mortality among patients with diabetes …
WEBNov 22, 2010 · Metformin use may decrease mortality among patients with diabetes when used as a means of secondary prevention, including subsets of patients in whom metformin use is not now recommended. Metformin use should be tested prospectively in this population to confirm its effect on survival.
Metformin Use and Clinical Outcomes Among Patients With …
WEBJul 31, 2019 · In a cohort of 12 156 patients with type 2 diabetes mellitus and high cardiovascular risk, metformin use was associated with lower rates of all-cause mortality, including after adjustment for clinical variables and biomarkers, but not lower rates of the composite end point of cardiovascular death, myocardial infarction, or ischemic stroke.
Efficacy and safety of metformin in the management of type 2 …
WEBOct 16, 2017 · Roussel et al. 2010 : Prospective, observational registry: To assess whether metformin use was associated with difference in mortality after adjustment for baseline differences and for the propensity to receive metformin among diabetics with established coronary artery disease, cerebrovascular disease, or peripheral arterial disease. P: 19,553
Metformin use and mortality in patients with advanced chronic …
WEBJun 17, 2015 · Use of metformin in people with type 2 diabetes and a serum creatinine concentration greater than 530 μmol/L is associated with a significantly increased risk of all-cause mortality compared with non-users. Metformin use should not …
Metformin Uniquely Prevents Thrombosis by Inhibiting Platelet ...
WEBNov 2, 2016 · Here we show, metformin prevents both venous and arterial thrombosis with no significant prolonged bleeding time by inhibiting platelet activation and extracellular mitochondrial DNA (mtDNA)...
The FDA and the EMA allow the use of metformin in patients with ...
WEBApr 14, 2015 · The EMA has finally authorized the use of metformin at a total maximum dose of 2000 mg in patients with eGFR 45-59 and 1000 mg for patients with eGFR 30-44 mL/min/1.73 m2) [2].
Metformin: clinical topics and new mechanisms of action
WEBDec 9, 2016 · Metformin is a widely used orally administerd glucose-lowering drug for type 2 diabetes and is recommended as a first-line drug in recent treatment guidelines of the American Diabetes Association (ADA) and European Association for the Study of Diabetes (EASD) .
Monitoring Patients on Metformin: Recent Changes and Rationales
WEBDec 10, 2017 · Roussel R, Travert F, Pasquet B. et al; Reduction of Atherothrombosis for Continued Health (REACH) Registry Investigators. Metformin use and mortality among patients with diabetes and atherothrombosis.
Metformin treatment is associated with improved outcome in …
WEBJul 29, 2022 · The role of metformin (MET) in the treatment of patients with advanced HFrEF and type 2 diabetes mellitus (DM) is not firmly established. We studied the impact of MET on metabolic profile, quality of life (QoL) and survival in these patients.
Metformin Use and Clinical Outcomes Among Patients With …
WEBJul 31, 2019 · Roussel R, Travert F, Pasquet B, Wilson PW, Smith SC, Goto S, Ravaud P, Marre M, Porath A, Bhatt DL, et al; Reduction of Atherothrombosis for Continued Health (REACH) Registry Investigators. Metformin use and mortality among patients with diabetes and atherothrombosis. Arch Intern Med. 2010;170:1892–1899. doi: 10.1001/archinternmed.2010.409