Bishopville is a town in Lee County, South Carolina, United States. The population was 3,471 at the 2010 census. It is the county seat of Lee …Bishopville is a town in Lee County, South Carolina, United States. The population was 3,471 at the 2010 census. It is the county seat of Lee County. Bishopville is located at 34°13′8″N 80°14′56″W / 34.21889°N 80.24889°W near Lee State Park.