Cayuga Inlet is a river located in Tompkins County, New York. It flows into the south end of Cayuga Lake by Ithaca, New York. Cayuga Inlet is a popular and well-connected location for boating. Boaters are able to travel from Cayuga Inlet via the Erie Canal and Saint Lawrence Seaway to the Atlantic Ocean, or follow Lake Erie to the Mississippi River and the G…Cayuga Inlet is a river located in Tompkins County, New York. It flows into the south end of Cayuga Lake by Ithaca, New York. Cayuga Inlet is a popular and well-connected location for boating. Boaters are able to travel from Cayuga Inlet via the Erie Canal and Saint Lawrence Seaway to the Atlantic Ocean, or follow Lake Erie to the Mississippi River and the Gulf of Mexico. Because of this, waterfront property values are high.