Independence is a city in Trempealeau County, Wisconsin, United States. The population was 1,498 at the 2020 census. It is located at the con…Independence is a city in Trempealeau County, Wisconsin, United States. The population was 1,498 at the 2020 census. It is located at the confluence of Elk Creek and the Trempealeau River. Unless otherwise noted, the history below is taken from a local historical album published for the city's centennial in 1976.
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