The 49ers are likely to be without Christian McCaffrey, Deebo Samuel and now George Kittle against the Rams on Sunday

After a strong start with a 32-19 win against the New York Jets in Week 1 and the 23-17 loss against the Minnesota Vikings, the San Francisco 49ers are now headed to California. The post 49ers Injury Update: George Kittle Doubtful,

For San Francisco, tight end George Kittle (hamstring) is doubtful, defensive end Nick Bosa (rib) and cornerback Charvarius Ward (hamstring, knee) are questionable, and receiver Deebo Samuel (calf) is out.