Under these conditions, it has been widely believed that the entry of mitochondrial calcium augments mitochondrial ATP production to acutely match the rapid increase in ATP demand 11,16,17,18.

From calcium storage to heat generation, mitochondria are hugely important to our cells’ everyday functions. Mutations or damage to mitochondrial DNA can also lead to certain disorders ...

The first 3D map of mitochondria in the human brain has been created, revealing how brain energy influences cognitive aging.

The balance of mitochondrial Ca 2+ is maintained through interactions between uptake and efflux mechanisms. Key players in the process include the mitochondrial calcium uniporter (MCU) complex for ...

Synaptic transmission is an energy hog. It requires neurons to tap ATP reserves to respond to incoming signals. How do they pull this off, thousands to millions of times per day? A new study ...

Intracellular calcium dynamics has been shown to be essential for the initiation of the autophagy process. Mitochondria are a major calcium store within the cell and mitochondria import cytosolic ...

A new mouse study from Massachusetts General Hospital has for the first time established a connection between elevated levels of calcium in mitochondria and neuron death associated with the ...

This resistance raised questions about their specialized function. Previous research has indicated the mitochondrial calcium uniporter’s (MCU) role in coupling neuron activity and mitochondrial ATP ...

The main function of mitochondria is to generate the energy needed to power a cell’s biochemical reactions in the form of adenosine triphosphate (ATP). Mitochondria have their own set of DNA referred ...