ATP, the fuel of life, is produced in mitochondria of living cells by a molecular machine, the ATP synthase. Researchers have isolated the machines from four fungal species, compared their ...

ATP synthase is a universal molecular machine for energy conversion. By coupling to cellular respiration in mitochondria, it catalyzes conversion of chemical energy of cells. Mitochondrial ATP ...

The mitochondrial ATP synthase is energy-converting macromolecular machine that uses the electrochemical potential across the bioenergetic membrane called cristae. This potential is maintained via ...

F1FO-ATP synthase is critical for mitochondrial functions. The deregulation of this enzyme results in dampened mitochondrial oxidative phosphorylation (OXPHOS) and activated mitochondrial ...

The experimental drug J147 is something of a modern elixir of life; it’s been shown to treat Alzheimer’s disease and reverse aging in mice and is almost ready for clinical trials in humans. Now, Salk ...

The discovery is remarkable, Lehmann says, not just for outlining a new role for the mitochondria beyond energy production, but also because it appears that ATP synthase's role in stem cell ...

Chimeric SFT2D2‐TBX19 Promotes Prostate Cancer Progression by Encoding TBX19‐202 Protein and Stabilizing Mitochondrial ATP Synthase through ATP5F1A Phosphorylation , Advanced Science, 11, 48 ...

Dual role of Mic10 in mitochondrial cristae organization and ATP synthase-linked metabolic adaptation and respiratory growth. Cell Reports , 2022; 38 (4): 110290 DOI: 10.1016/j.celrep.2021.110290 ...

Mechanistically, these muropeptides were shown to enter intestinal-cell mitochondria to interact with the F1 complex of ATP synthase, stabilizing the complex and increasing mitochondrial respiration.

P5CS-containing mitochondria showed higher membrane potential, suggesting that they engage in reductive metabolism for proline and ornithine synthesis, while ATP synthase-enriched mitochondria are ...

Researchers Alexander Mühleip (Stockholm University) and Alexey Amunts (Stockholm University) solved the structure of a mitochondrial ATP synthase with native lipids. ATP synthase is a universal ...