Since actin is so essential to cellular function, its amino acid sequence has been highly conserved throughout evolution. For the actin cytoskeleton to perform these functions, its organization ...

Studies have found that aging alters actin expression, disrupting the cytoskeleton’s functions, which can lead to age-related diseases, including cancer and neurodegenerative diseases.

Two recent papers from the Walker lab have now revealed the role of SETD2 in modifying the actin cytoskeleton and its implications for two important functions of cancer cells, cell migration and ...

The actin cytoskeleton is essential for maintaining ... recruitment of immune-inhibitory ligands to alter the cytotoxic function of immune cells. Finally, to validate their results, Dr. Al Absi ...

Actin filaments are composed of two intertwined ... proteome can vastly contribute to our understanding of cytoskeleton composition, function, regulation and dynamics. The opportunity to use ...

“If we want to understand how the synapse functions, we have to understand its organization ... To achieve this goal, Leterrier and his team decided to look at the actin cytoskeleton in the ...

“The actin cytoskeleton dictates the shape and polarity ... that are essential for maintaining cell structure and many other functions. The assembly and disassembly of actin filaments are ...

and genetic approaches to uncover the general principles underlying regulation of the actin cytoskeleton, and to reveal how defects in actin dynamics affect the physiological functions of cells.