Figure 1: Model of Spir and Cappuccino cooperation in actin nucleation/polymerization. Together these findings establish actin nucleation by multiple WH2 domains as a general mechansim.

These are members of a team from Rice University and Baylor College of Medicine that deciphered the 3-D structure of actin nucleation, a critical but fleeting process that takes place thousands of ...

It exists primarily as monomers (G-actin) bound by G-actin binding proteins that prevent spontaneous nucleation of new actin filaments, making nucleation the rate-limiting step in forming filamentous ...

But in 2008, Mukherjee stumbled across a new and much faster way to cause intracellular mayhem. Studying bacterial interactions with actin is still throwing up new mysteries. These microbes all enjoy ...