Key mediators underlying these effects are shown. The fate of activated stellate cells during resolution of liver injury is uncertain, but may include reversion to a quiescent phenotype and/or ...

Once activated, HSCs undergo a process of transdifferentiation ... Mechanisms of Epigenetic Regulation in the Fibrogenic ...

This buildup of collagen and other fibrous tissue accelerates when hepatic stellate cells become activated during hepatitis, often resulting in liver cancer or cirrhosis, both of which can be fatal.

The HepaStem cells have immunomodulatory properties, similar to other MSCs, and act on the hepatic stellate cells that drive hepatic fibrosis. These immunomodulatory, antifibrotic, and liver ...