DS mice show a marked increase in ... histological analysis of DS liver revealed increased fibrosis and steatosis, ... oxidative stress, liver, aging. Click here to sign up for free Altmetric ...

Using mice to model normal, healthy aging, investigators identified key pathologic changes in the liver that occur in middle-age, including steatosis (fatty liver disease) and collagen deposition.

Metabolic-associated steatohepatitis (MASH) is an advanced and progressive liver disease that potentially causes cirrhosis ...

Researchers have been able to reverse age-related damage to liver cells in mice and in human cell cultures in a new study. The study homes in on ferroptosis — a form of iron-dependent cell death ...

Steatotic liver disease is highly prevalent among adults having cardiometabolic risk factors, prolonged alcohol intake, or ...

Consistently, histological analysis of DS liver revealed increased fibrosis and steatosis, as shown by increased Colo1a11 expression, indicative of potential progression to liver cirrhosis.

In experiments using mice and liver tissue from humans, the researchers identified how the aging process prompts certain liver cells to die off. They were then able to reverse the process in the ...

Resolvin D2–G-Protein Coupled Receptor 18 Enhances Bone Marrow Function and Limits Steatosis and Hepatic Collagen Accumulation in Aging. The American Journal of Pathology , 2023; 193 (12): 1953 ...

Consistently, histological analysis of DS liver revealed increased fibrosis and steatosis, as showed by Col1a1 increased expression, indicative of potential progression to liver cirrhosis.

In a test, the therapy eliminated senescent cells in mouse models with liver and lung cancers. But surprisingly, the team also found that young mice receiving the treatment had better liver health and ...

The aging and failure of cells that occurs when the liver is damaged can spread to other organs, suggests a new study in mice and humans from researchers at UCL, the University of Edinburgh and ...