Data demonstrate that ATV-1601, a selective allosteric inhibitor of AKT1 E17K, provides enhanced target inhibition, superior efficacy and improved tolerability compared to pan-AKT inhibitors in ...

Esperion announces a novel allosteric ACLY inhibitor program targeting primary sclerosing cholangitis, enhancing its liver disease development portfolio. Quiver AI Summary.

Another type of inhibitor for an enzyme is an allosteric inhibitor. Another type of enzyme inhibitor, an allosteric inhibitor, causes a structural change of the enzyme, leading to the inhibition ...

EAI-432, an allosteric inhibitor, offers a new approach to targeting mutant-EGFR driven NSCLC By binding outside the ATP pocket, it co-binds with the current standard-of-care third generation EGFR ...

Asciminib is an allosteric inhibitor that binds a myristoyl site of the BCR-ABL1 protein, locking BCR-ABL1 into an inactive conformation through a mechanism distinct from those for all other ABL ki ...

"Our study brings a fresh twist by identifying the antibiotic ciprofloxacin as an allosteric inhibitor of ACE—instead of latching onto the active site like traditional inhibitors, ciprofloxacin ...

3D structural representation of ACE with ciprofloxacin bound (gray and blue) at allosteric site, away from the zinc-containing active site. Zinc ion in the active site is shown in magenta.