EAI-432, an allosteric inhibitor, offers a new approach to targeting mutant-EGFR driven NSCLC By binding outside the ATP pocket, it co-binds with the current standard-of-care third generation EGFR ...

Data demonstrate that ATV-1601, a selective allosteric inhibitor of AKT1 E17K, provides enhanced target inhibition, superior efficacy and improved tolerability compared to pan-AKT inhibitors in ...

"Our study brings a fresh twist by identifying the antibiotic ciprofloxacin as an allosteric inhibitor of ACE—instead of latching onto the active site like traditional inhibitors, ciprofloxacin ...

Asciminib is an allosteric inhibitor that binds a myristoyl site of the BCR-ABL1 protein, locking BCR-ABL1 into an inactive conformation through a mechanism distinct from those for all other ABL ki ...

Another type of inhibitor for an enzyme is an allosteric inhibitor. Another type of enzyme inhibitor, an allosteric inhibitor, causes a structural change of the enzyme, leading to the inhibition ...

Esperion announces a novel allosteric ACLY inhibitor program targeting primary sclerosing cholangitis, enhancing its liver disease development portfolio. Quiver AI Summary.

MARTINSRIED, Germany, Sept. 16, 2024 (GLOBE NEWSWIRE) -- Eisbach Bio GmbH (“Eisbach” or the “Company”), a privately-held clinical-stage biotechnology company pioneering cancer medicines ...

3D structural representation of ACE with ciprofloxacin bound (gray and blue) at allosteric site, away from the zinc-containing active site. Zinc ion in the active site is shown in magenta.

Nimbus is conducting a number of Phase 2 clinical studies to evaluate its novel allosteric TYK2 inhibitor, including an ongoing moderate-to-severe plaque psoriasis (NCT04999839) study and an ...

RLY-2608’s pan-mutant inhibition has the potential to address over 100,000 patients per year in the U.S. The data presented at the conference show that in preclinical models, RLY-2608 ...