Alpha-1 adrenergic receptors (α1-ARs) are a subset of G protein-coupled receptors that play a pivotal role in cardiovascular homeostasis. While traditionally recognised for their involvement in ...

Vasopressors can act on the alpha-1, beta-1, and beta-2 adrenergic receptors. They also can act on dopamine receptors. These drugs stimulate smooth muscle contraction in the blood vessels.

This article reviews the current state of knowledge and understanding of the genetic variation present in the three human beta-adrenergic receptor genes.

Among 351,297 Swedish men in the Stockholm PSA and Biopsy registry, 39,856 (11.3%) had filled at least 2 prescriptions for an alpha-1 adrenergic receptor antagonist.

Tamsulosin is a selective alpha 1A-adrenergic receptor antagonist. The effects of tamsulosin are targeted for the smooth muscle receptors of the prostate and urethra. Blocking this receptor relaxes ...

Preliminary data have also suggested that a single nucleotide polymorphism of the β-1 adrenergic receptor is overexpressed in African Americans. At position 389, glycine is substituted for arginine.

RAPAFLO is an effective, selective alpha-1 adrenergic receptor antagonist. ... In targeting the 1A receptors, organ-specific activity is maximized, and cardiovascular effects are minimized.

The Food and Drug Administration has granted Fast Track designation to APD418 (Arena Pharmaceuticals) for the treatment of decompensated heart failure.