In a nutshell Your cells learn to adapt to cold stress fast. In just seven days of daily cold plunges, participants’ cells shifted from emergency mode (inflammation and cell death) to a more efficient ...

Physiological Roles of Autophagy How much and what parts of the cell can be eaten without causing cell death? Scientists hypothesized that the level of autophagy and the cargo specificity must be ...

Researchers have found cold-water acclimation affects cellular function, upregulating protective mechanisms that could ...

If you've ever been cold water swimming, you'll know all about the short, sharp shock it gives your senses as you plunge in.

The Overholtzer lab studies mechanisms of nutrient sensing and cellular responses to nutrient starvation, including the nutrient recycling pathway autophagy, scavenging pathways such as ...

This study shows that poor oral health — particularly gum infections caused by Porphyromonas gingivalis — could make heart attacks more dangerous by interfering with the body’s ability to heal. It ...

My group focuses on understanding cell signaling pathways primarily linked with the ubiquitin and autophagy systems and frequently altered in diseases, including neurodegenerative disease. To this end ...

Different types of programmed cell death. This picture summarizes the different pathways of programmed cell death (Note: ROS: reactive oxygen species). By unveiling the complex interactions ...