Autophagy functions in numerous critical ... and brain of a mouse model. Eliminating the CMA pathway in the liver resulted in liver damage and decreased liver function, but no accumulation of ...

indicating that autophagy induction was essential for PARK7 secretion. Notably, inhibiting other protein degradation pathways, such as the ubiquitin–proteasome system, did not affect PARK7 ...

A research team has uncovered a new mechanism involving astrocytes for treating Alzheimer's disease (AD) and proposed a novel therapeutic target. In their study, the researchers revealed that an ...

To characterise location and expression of autophagy markers in 3D organotypic model of human skin disease models To establish a 3D model of “inflamed epidermis” To assess the effect of autophagy ...

This led to constant firing through the C53 autophagy pathway and greatly sensitized the plants to ER stress. Thus, the team demonstrated that sAIMs are essential for regulating C53-mediated ER ...

Pancreatic ductal adenocarcinoma (PDAC) is characterized clinically by poor survival and mechanistically by KRAS- and autophagy-dependent growth. We and others previously demonstrated that inhibition ...

The cellular pathway under study is called autophagy, a word that literally means "self-eating." This ancient mechanism is switched on by cells to destroy invading foreign material or consume its ...

Hydroxychloroquine inhibits autophagy at a later point in the pathway and, importantly, readily crosses the blood-brain barrier. "Most drugs do not efficiently cross the blood-brain barrier ...