The authors also concluded that amino acids (leucine in particular) do not inhibit autophagy via mTOR. It was suggested that amino acids could perhaps turn on different signaling pathways in ...

together with terminal kinases of various other stress-induced signaling pathways, converge on a common target, Unc-51-like kinase 1 (ULK1; Atg1 in yeasts) which consists of ULK1, autophagy ...

Among the hundreds of proteins that are secreted by Legionella pneumophila (the causative agent of Legionnaires’ disease) ...

Conventionally, proteins that are bound for secretion harbor an N-terminal signal ... autophagy induction was essential for PARK7 secretion. Notably, inhibiting other protein degradation pathways ...

Understanding the molecular pathways of autophagy can result in understanding and treating neurodegenerative disorders, metabolic disorders, and physiologic changes associated with aging. News ...

Both proteins are required for the normal function of inflammatory and autophagy pathways, and now we have ... Several compounds that affect TBK1 signaling have already been developed for use ...

Activated p53 negatively regulates mTORC1 signaling, which is one of the major kinases responsible for the phosphorylation of TFEB and TFE3. The autophagy-lysosomal pathway is activated via the ...

A research team has uncovered a new mechanism involving astrocytes for treating Alzheimer's disease (AD) and proposed a novel therapeutic target. In their study, the researchers revealed that an ...