Mutations in the BRCA1 gene that are either inherited (germline) or acquired (somatic) might not be key to the initiation of prostate cancer, as previously thought, suggests the first study of its ...

Sensitivity to ionizing radiation is compelling evidence that BRCA1-and BRCA2-deficient cells are defective in repair of DSBs. As discussed above, 2 separate pathways play major roles in DSB repair in ...

Opens in a new tab or window Share on LinkedIn. Opens in a new tab or window Mutations in BRCA1 do not appear to contribute significantly to the risk of prostate cancer progression, according to ...

Furthermore, depletion of PIAS1 and PIAS4 causes a decrease in DSB repair by homologous recombination ... is mediated by the E3 ubiquitin ligases BRCA1, RNF8 and RNF168. Galanty et al.