Mechanistically, BEL upregulated hepatic CYP7A1 to enhance bile acid synthesis and inhibited intestinal bile acid reabsorption by downregulating the ASBT and OSTα/β transporters.

Bile Acid Metabolism. Bile acids undergo a complex metabolic cycle known as the enterohepatic circulation. After aiding in digestion, bile acids are absorbed in the ileum and transported back to the ...

Bile acid is a component of bile and aids in the digestion and absorption of fats and related vitamins. Using the mouse model, researchers demonstrated for the first time that bile acid crosses ...

Medications that target bile acid-triggered pathways and combination therapies could be the key for treating nonalcoholic steatohepatitis for young people with obesity and type 2 diabetes ...

Bile acids are well recognized as essential for regulating cholesterol homeostasis and the digestion and absorption of fat through the intestine. In recent years they have emerged as signaling ...

Moreover, age-related reductions in bile acid synthesis reduces the utilization of cholesterol. These changes are collectively associated with excessive accumulation of cholesterol in the body.

Bile acid reabsorption from the distal ileum is dependent on ASBT; ... glucose metabolism, and the synthesis of cholesterol and fatty acids. Thus, this therapeutic strategy, ...

SCARB2 Deficiency and Gut Dysbiosis: Scarb2 deficiency in mice is associated with gut dysbiosis and altered bile acid pools, leading to hyperactivation of FXR in the intestine, which impairs ...

In a paper in Nature, researchers at the Chinese Academy of Sciences and Xiamen University report that they have identified one such caloric restriction mimetic—a bile acid called lithocholic ...