Given that obeticholic acid decreases bile acid synthesis, the expectation was that it should therefore slow PBC progression when eventually put to clinical study. However, FDA staff noted ...

More information: Siva Karthik Varanasi et al, Bile acid synthesis impedes tumor-specific T cell responses during liver ...

Researchers are continuing to investigate many types of therapeutic targets with NASH, some of which involve bile acid synthesis, such as FXR agonists or fibroblast growth factor (FGF) 15/19 ...

This disruption affects the signaling pathway involving FXR, which normally regulates bile acid synthesis and intestinal lipid absorption. The hyperactive FXR in Scarb2-deficient mice leads to a ...

Mirum will acquire Travere’s rights to Cholbam®, indicated for the treatment of bile acid synthesis disorders due to single enzyme deficiencies and adjunctive treatment of peroxisomal disorders ...

Mechanistically, BEL upregulated hepatic CYP7A1 to enhance bile acid synthesis and inhibited intestinal bile acid reabsorption by downregulating the ASBT and OSTα/β transporters. This dual ...

These bile acids, which are derived from the CYP7B1-centered alternative bile acid synthesis pathway, exhibit high efficacy in regulating glucose metabolism and predicting type 2 diabetes.

Bile acids activate farnesoid X receptor (FXR) to repress the expression of CDO1 and CSAD to inhibit taurine synthesis and at the same time repress cholesterol 7⍺-hydroxylase (CYP7A1 ...

Mirum will acquire Travere's rights to Cholbam, indicated for bile acid synthesis disorders due to single enzyme deficiencies and adjunctive treatment of peroxisomal disorders in patients who show ...

The GLP-1 receptor agonist also increased reabsorption of bile acids more effectively ... selenium-homotaurocholic acid test [SeHCAT]), and also decreased bile acid synthesis (assessed by ...