Hepatic synthesis of bile acids is the primary pathway for cholesterol catabolism. The cholesterol 7α-hydroxylase enzyme (encoded by CYP7A1) represents the rate-limiting step of the multi ...

Bile acids help the digestive system break down fats into forms the body can take up and use. "But it has now become clear that bile acids are more than just digestive aids; they act as signaling ...

Combining a statin with a bile acid sequestrant, fibrate or ezetimibe can help achieve lipid goals, and a bile acid sequestrant has the unique ability to reduce LDL-C, while improving glycemic ...

Cholesterol absorption inhibitors, like statins, are associated with a reduced risk of developing liver cancer. Previous ...

A new study sheds light on changes to the fetus's bile acid, which affects how liver disease develops and progresses. When mothers eat a diet high in fat and sugars, their unborn babies can ...

A study shows that the semi-synthetic bile acid NorUDCA inhibits in the intestine the formation of pro-inflammatory T helper 17 cells (TH17) and at the same time promotes the generation of anti ...

The research teams led by Kristina Schoonjans and Rizlan Bernier-Latmani at EPFL, have identified Clostridium scindens, a bacterium that converts primary bile acids into 7α-dehydroxylated bile ...

Dietary therapy can be useful as adjunctive therapy to medication: Replacing animal protein with soy protein can reduce total cholesterol ... patients. The bile acid sequestrants can reduce ...