A recent review by researchers at Philadelphia College of Osteopathic Medicine (PCOM) shows Chlamydia pneumoniae (Cpn) and ...

It demonstrates that macrophage-derived IFN-β stimulates the IFN-β-IFNAR-p-STAT1 axis in CFs, leading to the upregulation of chemokines (CCL2/7/12) that attract more macrophages.

Morphine has previously been shown to stimulate CCL2 expression in other cell types, [] and other investigators have shown that neurons constitutively express CCL2. [9,10,11,12,13] However, this ...

In summary, macrophages secrete IFN-β, activating the IFN-β-IFNAR-p-STAT1 axis in MICFs, leading to increased secretion of CCL2/7/12 chemokines and subsequent recruitment of more IFN-β ...

Methods: CNTO 888 was administered as a 90-minute infusion on days (d) 1, 29 (for pharmacokinetic [PK] assessment) and q14d thereafter. Pre- and post-therapy pharmacodynamic [PD] evaluation included ...

Astrocytic Slc4a4 regulates blood-brain barrier integrity in healthy and stroke brains via a CCL2-CCR2 pathway and NO dysregulation. Cell Reports, 2024; 43 (5): 114193 DOI: 10.1016/j.celrep.2024. ...

This study elucidates the complex interplay between macrophages and CFs in the MI microenvironment, highlighting the role of the IFN-β-IFNAR-p-STAT1 signaling pathway as a critical barrier to ...