A recent review by researchers at Philadelphia College of Osteopathic Medicine (PCOM) shows Chlamydia pneumoniae (Cpn) and ...

It demonstrates that macrophage-derived IFN-β stimulates the IFN-β-IFNAR-p-STAT1 axis in CFs, leading to the upregulation of chemokines (CCL2/7/12) that attract more macrophages.

Morphine has previously been shown to stimulate CCL2 expression in other cell types, [] and other investigators have shown that neurons constitutively express CCL2. [9,10,11,12,13] However, this ...

In summary, macrophages secrete IFN-β, activating the IFN-β-IFNAR-p-STAT1 axis in MICFs, leading to increased secretion of CCL2/7/12 chemokines and subsequent recruitment of more IFN-β ...

Metastasis occurs when tumor cells "migrate" to other organs through the bloodstream. Scientists have now discovered the trick tumor cells use to invade tissue from the blood vessels: They produce ...

This study elucidates the complex interplay between macrophages and CFs in the MI microenvironment, highlighting the role of the IFN-β-IFNAR-p-STAT1 signaling pathway as a critical barrier to ...

Astrocytic Slc4a4 regulates blood-brain barrier integrity in healthy and stroke brains via a CCL2-CCR2 pathway and NO dysregulation. Cell Reports, 2024; 43 (5): 114193 DOI: 10.1016/j.celrep.2024. ...

Results: 44 pts (21M/23F) were treated with CNTO 888: 21 pts in dose-escalation cohorts (0.3, 1, 3, 10, and 15 mg/kg) and 23 pts in 2 dose-expansion cohorts (10 and 15 mg/kg). Reversible grade (G) 3 ...

Original publication: Monika Wolf et al., 2012. Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway, Cancer Cell, 07/2012. Contact: ...