for the treatment of CCR5-tropic human immunodeficiency virus (HIV) infection as part of an optimized antiretroviral regimen in treatment-experienced patients. As 50% or more of treatment ...

Two more people have been potentially cured of HIV after receiving stem cell transplants to treat blood cancer or bone marrow ...

The virus could have spread to humans who were hunting ... HIV infects cells by attaching to a protein on their surface, called CCR5. Some people have a genetic mutation that changes the shape ...

In addition to switching to the coreceptor CXCR4, the virus can adapt to use CCR5 in the presence of the coreceptor blocker, or preexisting minority variants can emerge that use CXCR4. In fact ...

Other targets for entry inhibitors include two co-receptors on the cell surface—CCR5 and CXCR4—which together with CD4 mediate virus binding and membrane fusion 3. As CCR5, but not CXCR4 ...

Among the CCR5 inhibitors developed so far ... whereas the V1/V2 region is involved in effective entry of the virus. Impact of nonfunctional chemokine receptor alleles on HIV resistance & disease ...

Dr He used CRISPR or Cas9, which stands for CRISPR-associated protein 9, to target a gene called CCR5, which codes for a protein used by the human immunodeficiency virus-1 (HIV-1) to enter cells.

He stopped antiretroviral treatment 16 months after the transplant, by which time all his CD4 cells lacked CCR5 receptors. Still controlling the virus without ART a year later, Castillejo went public.

Since its introduction in 1987, antiretroviral therapy has transformed human immunodeficiency virus (HIV ... likely to carry one copy of the gene CCR5 with a Δ32 deletion and one copy without ...