NSAIDs work on a chemical level. They block the effects of special enzymes -- specifically Cox-1 and Cox-2 enzymes. These enzymes play a key role in making prostaglandins. By blocking the Cox ...

All NSAIDs variably inhibit COX-1 and COX-2 and the mechanisms of inhibition ... NSAID inhibition of COX in vitroare the source of the enzyme, the Michaelis constant (K m)of the endogenous ...

COX-1 protects the stomach lining and regulates blood platelets, while COX-2 is primarily associated with inflammation and ...

"Ibuprofen and other nonsteroidal anti-inflammatory drugs (NSAIDs) work by inhibiting cyclooxygenase enzymes, COX-1 and COX-2, which are used by the body to make signaling molecules called ...

Table 1. Example of the range of IC 50 ... Important considerations when investigating NSAID inhibition of COX in vitroare the source of the enzyme, the Michaelis constant (K m)of the endogenous ...