There are numerous methods of inducing autophagy including nutrient starvation and rapamycin which both inhibit mTOR signalling. The lack of nutrients such as serum and amino acids in the cell ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly ...

Autophagy can also lead to the arrest of the cell cycle, although it is not clear if this process is dependent or independent of the TOR signaling. Dr. Ananya Mandal is a doctor by profession ...

A new FEBS Letters review explores the dual role of autophagy in cancer and protein misfolding diseases—highlighting its ...

CHRONIC LIVER diseases, such as alcoholic, viral, autoimmune, and metabolic liver disorders, often progress to fibrosis and cirrhosis due to persistent inflammation. This inflammatory environment is ...

Sometimes, autophagy destroys some of these molecules and parts. Other times, the cell recycles these parts into new components. The term “autophagy” derives from the Ancient Greek for “self ...

Autophagy (“self-eating”) is the process through which parts of the cell are degraded in the lysosome. Elucidation of the key genes essential for autophagy — originally identified in yeast ...

Oscar Wong//Getty Images When that happens, the parts become junk or litter inside a healthy cell. Autophagy cleans out the junk so new healthy cells can be created. “We constantly have ...

More information: Sebastian J. Hofer et al, Spermidine is essential for fasting-mediated autophagy and longevity, Nature Cell Biology (2024). DOI: 10.1038/s41556-024-01468-x Journal information ...