In this study, ARHI-induced ovarian cancer cell death in culture has been found to depend upon autophagy and has been linked to G1 cell-cycle arrest, enhanced reactive oxygen species (ROS ...

There are numerous methods of inducing autophagy including nutrient starvation and rapamycin which both inhibit mTOR signalling. The lack of nutrients such as serum and amino acids in the cell ...

A Non-Cell-Autonomous Role of BEC-1/BECN1/Beclin1 in Coordinating Cell-Cycle Progression and Stem Cell Proliferation during Germline Development. Current Biology , 2017; DOI: 10.1016/j.cub.2017.02.015 ...

Scientists at Novartis and Pfizer independently conducted autophagy-inhibition experiments in dozens of cancer cell lines, and they teamed up to publish a study in 2015 concluding that the ...

Researchers from University of Athens and National Centre For Scientific Research “Demokritos” have reported preclinical data from a study that aimed to assess the novel cryptochrome-2 (CRY2) ...

Previous efforts to enhance HR activity, such as modulating the cell cycle or inhibiting NHEJ, have been limited by toxicity and poor compatibility across diverse systems.

Autophagy is one of two mutually antagonistic mechanisms by which cells respond to stress; the other mechanism is apoptosis, or programmed cell death . 3,4 As tumor cells up-regulate antiapoptotic ...

If the cell cycle were like a particular score played by a molecular orchestra, E2F7 was a new conductor, guiding the same instruments in that orchestra to play a new tune, the multiciliation cycle.

Analysis of cell cycle was performed by flow cytometry and apoptosis by Annexin-V binding. Molecular changes were determined by western blot . Results: CCI-779 induced cell growth arrest in all cell ...

Autophagy works in cell nucleus to guard against start of cancer. ScienceDaily. Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2015 / 10 / 151029101144.htm.

Cell biologist Yoshinori Ohsumi wins the 2016 Nobel Prize in physiology or medicine for discoveries in autophagy. ... Think of autophagy as a cell’s internal spa or recycling plant.