During each phase, the cell undergoes a series of events that prepare it for the next phase. Cell cycle checkpoints are control mechanisms that ensure that the cell cycle proceeds in a timely and ...

The book on ‘Cell Cycle Checkpoints and Cancer’, edited by Mikhail Blagosklonny, is such a brave attempt, and a very successful one indeed. The editor himself is one of the recognized leading ...

The cell must also pass through a series of checkpoints that ensure conditions are favorable for division. In order to move from one phase of its life cycle to the next, a cell must pass through ...

The stages of this cycle include ... Finally, M cyclins increase in mitosis and fall once the cell has passed the spindle formation checkpoint. They aid the formation of spindles and chromosome ...

cause the induction of p53 protein and cell cycle disruption. This process is crucial to understand fundamental biological processes and the emergence of various diseases. Now, scientists at the ...

Through these events, normal cells can become malignant. PT162 was designed to act as a p53-reactivating cell cycle checkpoint inhibitor, inducing cancer cell cycle arrest and/or apoptosis by ...

CDKs function to phosphorylate many different proteins which are required for passing important points in the cell cycle, called checkpoints. These checkpoints are present at the end of G1 and the ...