Hypoxia-driven gene and protein changes enhance epithelial-to-mesenchymal transition, remodel the extracellular matrix, drive drug resistance, support cancer stem cells and aid evasion from immune ...

Most recently we have examined how mitochondria function as intracellular sensors that allow cells to adapt to hypoxia. We have found that mitochondrial cytochrome c oxidase produces nitric oxide when ...

The intestine has an enormous ability to regenerate itself after injury, and it does this through a model of dedifferentiation. The cells dedifferentiate back into a type of regenerative stem cell ...

The nitrate-nitrite-NO pathway is emerging as an important mediator of blood flow regulation, cell signaling, energetics and tissue responses to hypoxia ... against IR injury in the heart ...