Cytosine is one of the four main nitrogenous bases found in DNA and RNA, along with adenine (A), guanine (G), and thymine (T) or uracil (U). It is a pyrimidine derivative, meaning it has a single-ring ...

Targeted methylation of cytosine residues by S-adenosylmethionine–dependent DNA methyltransferases modulates gene expression in vertebrates. Here we show that cytosine-5-methyltransferases ...

It is a qualitative, quantitative, and efficient approach to identify methylated cytosine at single base-pair resolution. 3. Bisulfite Conversion of Methylated Cytosine. Cytosine methylation occurs ...

Chinese scientists have found that cytosine base editors (BE3 and HF1-BE3) induce genome wide off-target mutations. Researchers from Huntsman Cancer Institute (HCI) at the University of Utah have ...

Researchers developed a WGS method that read four canonical DNA bases, viz., adenine (A), cytosine (C), guanine (G), and thymine (T) plus 5mC and 5hmC, epigenetic variants of unmodified C to yield ...

This trial was comparing a drug called barasertib (also known as AZD1152) with a low dose of cytosine arabinoside chemotherapy for people over 60 who had acute myeloid leukaemia (AML) and couldn’t ...