The expression of symptoms of viral infections is a byproduct of complex virus-host molecular pathways. These remain largely ...

The molecular pathways involved in antiviral defenses and counter-defenses in host-pathogen systems remain unclear. Researchers have used Neurospora crassa as a model organism to explore how RNA ...

C2H2 zinc finger proteins are the largest group of DNA-binding factors for transcription—the process of copying genetic information from DNA to messenger RNA (mRNA). As there are more than 700 ...

ATX-559, a first-in-class oral DHX9 inhibitor, is being evaluated in a Phase 1/2 study with a focuson advanced or metastatic ...

Somatic hypermutation (SHM) of immunoglobulin variable (V) regions modulates antibody-antigen affinity is initiated by activation-induced cytidine deaminase (AID) on single-stranded DNA (ssDNA).

In a new study published in Cell Reports, researchers at the University of Freiburg reveal how a disordered protein segment ...

This manuscript characterizes a mutated clone of RNA polymerase I in yeast, referred to as SuperPol, to understand the mechanisms of RNA polymerase I elongation and termination. The authors present ...

Other proteins modulate the formation of alternative structures, such as Z-DNA and G-quadruplexes, that are important in reloading the RNA polymerase enzymes after each transcription cycle.

DNA and RNA methylation, initially thought to operate as distinct ... the accessibility of specific genes for transcription. The second, DNA methylation, primarily involves the direct methylation of ...

The RNP complex is the influenza virus’s essential package, the virus’s blueprints and a copy machine all rolled in one. The ...

However, the Mount Sinai team discovered something surprising: these sites actually have opposing functions that control how fast RNA is copied from DNA. In other words, CTR1 acts like an ...