DNA polymerase μ (Pol μ) ... We observed no further major conformational changes of protein subdomains, DNA or active site side chains after substrate binding and throughout the catalytic cycle.

Here we report a recurring heterozygous single-codon deletion in POLD1 affecting the polymerase active site that abolishes DNA polymerase activity but only mildly impairs 3′- to 5′-exonuclease ...

Thioredoxin, which is ubiquitous in cells, binds to TBD, triggering a conformational change that helps TBD enhance the polymerase’s processivity. “So, it was along the same lines as thinking about if ...

RNA Polymerase Active Site Cavity Deforms the DNA Building Blocks. To understand how RNA polymerases avoid using DNA building blocks, ...

(1996) Structure of Taq polymerase with DNA at the polymerase active site. Nature. doi:10.1038/382278a0. Further Reading. All Biochemistry Content; What is Biochemistry?

Investigators may have uncovered the general mechanism that governs RNA polymerase movement, they report in the January 28 issue of Cell.. The finding "provides a framework for understanding how ...

New study shows RNA polymerase I halts at abasic DNA damage, ... The A12 subunit gains access to the active site and assists with RNA cleavage, halting further elongation and reducing bypass.

Tumors with compromised ability to repair double-strand DNA breaks by homologous recombination, including those with defects in BRCA1 and BRCA2, are highly sensitive to blockade of the repair of DNA ...