Today, scientists are hunting down a different kind of shape-shifting entity in search of answers about the inner workings of cellular life: intrinsically disordered proteins. Unlike their well-known, ...

Intrinsically disordered proteins (IDPs) do not attain a stable secondary or tertiary structure and rapidly change their conformation, making structure prediction particularly challenging.

“They are very common.” Lindorff-Larsen estimates that about one-third of human proteins contain these so-called disordered regions. Computational biologist Francesco Pesce, Ph.D., working ...

This dogma is challenged by intrinsically disordered proteins, which make up one-third of all proteins and have central biological functions even though their shapes are constantly changing.

Disordered proteins differ from other protein types as they are not neatly folded to have a three-dimensional structure, giving them a unique flexibility which is key to their function and how ...

But that's only most proteins. Scientists have also found a growing catalog of intrinsically disordered proteins. Rather than having a set structure, intrinsically disordered proteins seem to have ...

Researchers have created a standardized mouse stem cell library containing 63 genetic variants strongly linked to autism ...

LONDON and BELLINZONA, Switzerland, Jan. 9, 2025 /PRNewswire/ -- Peptone, a biotech company developing novel therapeutics targeting intrinsically disordered proteins (IDPs) to treat diseases ...

Muscularity oriented disordered eating refers to the disordered eating habits people may adopt in their drive to gain muscle ...