The response of patients with these diseases to diuretics, which is related to the dose, is best described by a sigmoid curve whose contour can become distorted by any of the several sodium ...

This rate of drug delivery resides on the steep portion of the sigmoidal-shaped diuretic dose-response curve and is situated between the threshold concentration (or minimally effective dose ...

Loop diuretics have steep dose–response curves, with plateaus often reached at commonly used doses . These agents are often called threshold drugs, suggesting that increasing doses beyond a ...

The measure of response is the loss of body weight twenty-four hours after the dose. From dosage-response curves for the standard and the unknown, ... a dose that produced a small diuretic effect.

which all suggest that diuretic response should be determined based on the effect of diuretic dose administered. Several strategies have been proposed to overcome diuretic resistance, including ...

Loop diuretics are widely used in the management of edema and heart failure.They are also widely misunderstood. The reason is this: Loop diuretics are often prescribed in a dose-dependent strategy.

MOJAVE – US Phase 1/2a study of DSR 2.0 for treatment of heart failure Previously reported strong data maintained after three-months follow-up: Diuretic response remained nearly normalized, with ...