The response of patients with these diseases to diuretics, which is related to the dose, is best described by a sigmoid curve whose contour can become distorted by any of the several sodium ...

This rate of drug delivery resides on the steep portion of the sigmoidal-shaped diuretic dose-response curve and is situated between the threshold concentration (or minimally effective dose) and ...

The measure of response is the loss of body weight twenty-four hours after the dose. From dosage-response curves for the standard and the unknown, ... a dose that produced a small diuretic effect.

Mild tolerance to loop diuretics can develop over time, requiring a higher dose. Common myths about loop diuretics include avoidance in sulfa allergy and discontinuation if the creatinine level rises.

Loop diuretics are administered in up to 90% of patients hospitalized for acute heart failure, despite the lack of evidence for outcome benefit. 2,3 Poor response to diuretic therapy (that is ...

Alicia Mecklai, MD, from the Weill Medical College of Cornell University in New York City, and colleagues examined the correlation between loop diuretic dose-response and post-discharge outcomes ...

MOJAVE – US Phase 1/2a study of DSR 2.0 for treatment of heart failure Previously reported strong data maintained after three-months follow-up: Diuretic response remained nearly normalized, with ...