Here we predict bnAb potency at therapeutic levels by analysing dose–response curve slopes, and show that slope is independent of IC50/IC80 and specifically relates to bnAb epitope class.

Even stranger, the dose response curve for endocrine disruptors may be “non-monotonic” — that is, not show a consistent relationship between increasing dose and increasing effect.

Figure 1: Effect of slope (m) on dose-response curves of antiretroviral drugs. Although there may be different mechanistic explanations for high slope values, our demonstration that the slope is a ...

A dose-response curve is the graphical representation of a dose-response relationship, the magnitude of response of an organism from exposure to drugs and chemical interactors.

Nonmonotonic dose-response curves, meaning a non-linear dose-response interaction, are widely observed in biology, especially in studies that involve responses to hormones and endocrine-disrupting ...

Mean BMI was 29.6 kg/m 2 in those with secondary adrenal insufficiency, ... or ACTH, dose-response curve, according to findings published in Journal of the Endocrine Society. ...

“Dose-response meta-analysis does not require a specific shape of the dose-response curve and allows ... 95% CI, 0.31-0.57; standardized mean difference for Positive and Negative ...

A hypothetical dose-response curve can be seen in Figure 1, with varying features including (i) the potency (the location of the curve along the dose axis), (ii) the maximum efficacy (the maximum ...