Eph receptors are activated by the autophosphorylation of tyrosine residues upon the binding of their ligands, ... ephrin-A2 can promote or inhibit the growth of retinal axons 12. In addition, ...

Effects of Eph Receptor Expression or Silencing in Malignancy. ... EphA7 is expressed in ependymal cells, with reverse signaling via Ephrin-A2 resulting in negative regulation of neuro-genesis.

Reference: Oki M, Yamamoto H, Taniguchi H, Adachi Y, Imai K, Shinomura Y. Overexpression of the receptor tyrosine kinase EphA4 in human gastric cancers. World J Gastroenterol 2008;14(37): 5650-5656 ...

The guidance system itself – the ephrins and Eph receptors – are found on the cell surface. When the ephrin and the Eph receptor of two opposing cells meet, they form an ephrin/Eph complex. This ...

When cells grow and divide, they come into contact with other cells. This happens not only during development and regeneration and after injury, but also during cancer growth and the formation of ...

The role of dynamics in protein functions including signal transduction is just starting to be deciphered. Eph receptors with 16 members divided into A- and B- subclasses are respectively activated by ...

Researchers at UT Southwestern Medical Center at Dallas have discovered a biochemical pathway that helps describe how neurons in the brain and spinal cord form their connections. Further study ...

Eph receptors are proteins initially investigated by Bing-Cheng Wang, a professor of pharmacology at Case Western Reserve's School of Medicine, for their role in brain development and cancer. They ...