AstraZeneca's camizestrant and Pfizer's vepdegestrant extended progression-free survival in trials in advanced ESR1-mutated breast cancer.

Figure 3 summarizes the multiple estrogen-receptor signal-transduction pathways, emphasizing effects associated with increased proliferation and inhibition of apoptosis. Table 3 lists selected ...

Chronic obstructive pulmonary disease (COPD) is an irreversible inflammatory lung disease. Studies have shown that ...

in patients with hormone receptor–positive advanced breast cancer are limited. Overall, 708 patients underwent randomization; 289 patients (40.8%) had AKT pathway alterations, and 489 (69.1% ...

Researchers have identified the receptor pathway used by estrogen to decrease liver injury after trauma and hemorrhage. The related report by Hsieh et al, "G protein-coupled receptor 30-dependent ...

Modulation of Estrogen Receptor-α (ERα): PR acts as a modulator of ERα, how estrogen receptor pathways drive tumor growth. This is key to understanding the different responses to hormone therapies.

Although estrogen-related receptors were discovered more recently ... “This redundancy is one of the indicators of how important this pathway is for animal and human physiology,” Fan added.

offering a novel pathway to tailored managements in hormone receptor-positive, HER2-negative breast cancer using readily available clinical imaging data." In conclusion, this study connects ...