Institut Curie researchers have identified a sex-specific molecular pathway connecting E-cadherin loss, estrogen receptor-α ...

The classic estrogen receptor signaling pathway occurs through the entry of estrogen into the cell, translocation to the nucleus, interaction with the nuclear estrogen receptor (ER) α or β, DNA ...

This estrogen receptor activated the STAT3 pathway, which has already been linked to cancer cell survival and the expansion of MDSCs in cancer-bearing hosts.

Modulation of Estrogen Receptor-α (ERα): PR acts as a modulator of ERα, how estrogen receptor pathways drive tumor growth. This is key to understanding the different responses to hormone therapies.

Researchers found a molecular pathway that regulates the influence of sex hormones on Sars-CoV-2 infection ... “We found a protective role of raloxifene and other estrogen receptor modulators, ...

Targeting the estrogen receptor and HER2 pathways improved progression-free survival in patients with HR-positive, HER2-positive metastatic breast cancer. Findings from a recent clinical trial ...

Vepdegestrant is an oral proteolysis-targeting chimera (PROTAC) estrogen receptor (ER) degrader that directly harnesses the ubiquitin–proteasome system.In this phase 3, open-label, randomized ...

Estrogen Receptor-Positive (ER+) breast cancer is the most common type of breast cancer, accounting for about 70–80% of all cases [1], [4].This form of cancer is characterized by cells that have ...

Estrogen-related receptors (ERRs) regulate muscle mitochondria in mice, revealing a new potential drug targets for metabolic diseases. genprowebdirectory Facebook Linkedin RSS Twitter Youtube ...

A recent study uncovers the molecular signatures of mammographic calcifications in hormone receptor-positive, HER2-negative breast cancer. The research identifies distinct molecular traits ...

Patients with metastatic prostate cancer showed similar prostate-specific antigen (PSA) responded when treated with transdermal estradiol (tE2) patches and androgen receptor pathway inhibitors (ARPIs) ...