This important study shows that nutrient stress emanating from the microenvironment induces metabolic vulnerabilities in pancreatic ductal adenocarcinoma (PDAC). Using a combination of cell-based and ...

These drugs function by blocking synthesis of the enzymes used to release these fatty acids from the cell membrane, preventing the synthesis of prostaglandins. Steroid drugs are commonly used to ...

Obesity and related metabolic disorders, such as hyperlipidemia and non-alcoholic fatty liver disease, have become ...

Non-alcoholic fatty liver disease (NAFLD) is a hepatic metabolic syndrome resulting from lipid metabolic imbalance.

Dr. Wakil's early studies of the mechanisms of fatty acid synthesis established the basis for the current understanding of this vital process in biological systems. Dr. Wakil demonstrated the ...

Non-alcoholic fatty liver disease (NAFLD) is a hepatic metabolic syndrome resulting from lipid metabolic imbalance.

A fungus (C. neoformans) grown in three conditions: untreated, treated with a sub-lethal dose of the fatty acid synthase inhibitor NPD6433, and treated with a fluconazole. The number and virulence ...