Bioreactors are commonly operated in two different modes: fed-batch and perfusion. In classical fed-batch culture, cells are supplemented with a concentrated nutrient solution, which results in ...

Results. Enabling the (N-1) bioreactor with perfusion technology (Figure 3) achieved a VCD of 100E6 cells/mL in 11 days (data not shown).This intensified seeding process allowed the fed-batch ...

Fed-batch bioreactors address the issue of scarcity of nutrients over time, and additions of nutrients are added over the time course of the process to maintain the nutrient concentration. Perfusion ...

Designed to work with both continuous and fed-batch bioreactors, the Aizon Bioreactor Application provides a deep understanding of the customer’s bioprocess manufacturing lifecycle.

Fed-batch cultivation of animal cells using different medium design concepts and feeding strategies. L Xie 1 , D I Wang. Biotechnol Bioeng. 1994 May;43(11):1175-89. doi: 10.1002/bit.260431123 ...

Bioreactor calibration and monitoring is a key part of ... B. Automated Raman Feed-Back Control of Multiple Supplemental Feeds to Enable an Intensified High Inoculation Density Fed-Batch Platform ...

When used with a perfusion or fed-batch bioreactor, continuous chromatography can help reduce the amount of resins and buffers needed. It also provides greater flexibility for processes and uses a ...

Once in the lab, microbes were extracted from the sediment samples and then enriched using a no-flow, fed-batch bioreactor where ferrous iron was intermittently added to enhance the growth of iron ...