GABA A receptors are a family of pentameric chloride ion channels composed of combinations of any of 19 types of subunits. The most common combination is two α subunits, two β subunits, and one ...

They expressed its α1β3γ2L isoform, one of the most common in the human brain, in cell lines. After isolating the receptor and reconstituting it within nanodiscs, the researchers solved its structure ...

The GABA A-receptor family has a crucial role in neural inhibition in the human brain. New structures of a GABA A receptor highlight the mechanisms of crosstalk between its binding sites. Michaela ...

Scientists have revealed the molecular structure of a type of receptor that's crucial to brain development and function. 'This study shows the dominant assemblies and states of the GABA receptor.

A healthy brain balances “activate” and “inhibit” signaling in its neural microcircuitry, with the inhibitory signaling often provided by cell receptors for the neurotransmitter GABA.

Getting on 'the GABA receptor shuttle' to treat anxiety disorders. ScienceDaily . Retrieved June 3, 2025 from www.sciencedaily.com / releases / 2009 / 10 / 091022101532.htm ...

Depression is a complex condition correlated with multiple differences in brain function and mechanisms. A new paper spanning known data about the neurotransmitter GABA and its principal receptors ...

In two separate imaging studies, they used positron-emission tomography (PET) and two molecular tracers that bind to GABA A receptors to compare their availability in 27 adult nondisabled ASD ...

Neurosteroids act as positive modulators of GABA-A receptors. Chronic stress – a major risk factor for depression – decreases neurosteroid signaling, impairing the inhibitory balance, said Maguire, a ...