Professor Hirohide Saito (Department of Life Science Frontiers at CiRA / The University of Tokyo) and Assistant Professor ...

Gene circuits enable more precise control of gene therapy. ScienceDaily . Retrieved June 11, 2025 from www.sciencedaily.com / releases / 2025 / 04 / 250428221213.htm ...

Professor Hirohide Saito and his research team have developed a new approach to control mRNA translation using Cas proteins, ... By programming gene expression patterns as desired, ...

To help achieve more precise control of gene therapy, MIT engineers have tuned and applied a control circuit that can keep expression levels within a target range.

Researchers developed an RNA-based switch, the pA regulator system, to control gene expression in mammalian cells by modulating synthetic polyA signal cleavage, offering a novel approach for gene ...

The mRNA metabolism passively shapes the levels of an mRNA modification called m6A within a steady-state cell and upon stress.

The expression of genes has to be carefully regulated in cells; active genes give cells their identity and ability to function. Epigenetic features are just one way that cells control gene expression, ...

The model can be told to create synthetic fragments of DNA with custom criteria, for example: ‘switch this gene on in stem cells which will turn into red-blood-cells but not platelets.’ The model then ...

The study, “Global impact of unproductive splicing on human gene expression levels and traits,” was supported by funding from the National Institutes of Health (grants R01GM130738, R01HG011067 ...

Discovery Analysis Demonstrates Transformative Sensitivity of 95% with Specificity of 98% for the Detection of Pancreatic Cancer in Blood Samples Mainz Biomed Enters into Exclusive Licensing ...

Our lab focuses on post-transcriptional mechanisms that regulate the expression of genes in higher plants. In particular, we are interested in the fate of mRNA molecules because of their pivotal role ...