which in turn bind to regulatory sites in the DNA that effectively block RNA polymerase binding (Figure 3). The control of gene expression in eukaryotes is more complex than that in prokaryotes.

The research team introduced two key quantitative concepts - the transcriptional threshold  and jumping index  - to establish ...

As gene therapies continue to advance ... 1.9 times more potent than lot 1 based on total protein–normalized expression (Figure 1B, right panel). The assay showed excellent reproducibility ...

An elegant screening strategy unveils a molecular actor that connects widespread changes in mRNA processing with a nutrient-sensing protein modification.

To help achieve more precise control of gene therapy, engineers have designed a new control circuit that can keep gene expression levels within a target range. The method could be used to deliver ...

“Because I was working with experts in the field of maternal-fetal communication, my thought was, we need to figure out which cells are mom ... and macrophages showed the greatest changes in gene ...