Latest study leverages new constructs for nuclear localization signal (NLS) sequences to improve editing efficiency in human ...

A year later came another major breakthrough, as two groups described 2, 3 a novel gene-editing tool called CRISPR-Cas9 and demonstrated its use in eukaryotic cells. These two reports helped start ...

Plant breeding plays a vital role in ensuring global food security by increasing crop yields, improving nutritional quality ...

Genome editing has advanced at a rapid pace with promising results for treating genetic conditions—but there is always room ...

The recent discovery of CRISPR/Cas9 technology simplified engineering synthetic gene drives for diverse animal species. Nowadays, synthetic gene drives have been engineered in laboratory mosquitoes ...

CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...

In a new development, researchers have successfully created an efficient two-line system for hybrid seed production in ...

When the CRISPR Cas9 protein is added to a cell along with a piece of guide RNA, the Cas9 protein hooks up with the guide RNA and then moves along the strands of DNA until it finds and binds to a ...

Cas9, the first Cas protein repurposed for cutting DNA, introduces double-strand breaks that recruit DNA repair machinery. Despite its successes, the CRISPR-Cas9 system has several limitations, ...

CRISPR-Cas9 gene editing technology has emerged as one of the most transformative advancements in medicine and biotechnology. This precise tool allows scientists to make targeted modifications to ...

CRISPR-Cas9 is not the first method available to scientists for modifying DNA; it is by far, however, the easiest to use. With CRISPR-Cas9, the crRNA/tracrRNA sequence or an artificial guide RNA ...