He and his team at UD recently investigated a system of four enzymes that work together to both bring sugar into the cell and carry out a downstream step in its breakdown in a process called ...

At first glance, the result seems surprising, since the enzyme blockade inhibits the sugar degradation pathway in both cases.

The study is reported in the Journal of Experimental Medicine.The article describes the role of PKM2 (pyruvate kinase M2), the enzyme responsible for the final step of glycolysis, in the ...

However, when the researchers blocked an "earlier" step in glycolysis, the enzyme glucose-6-phosphate isomerase, this had no effect on the growth of the cancer cells. "The glycolytic enzyme aldolase ...

The article describes the role of PKM2 (pyruvate kinase M2), the enzyme responsible for the final step of glycolysis, in the development and maintenance of the exacerbated inflammation typical of ...

However, when the researchers blocked an earlier step in glycolysis, the enzyme glucose-6-phosphate isomerase, this had no effect on the growth of the cancer cells.