Hematopoietic stem-cell transplantation, which is used to treat both malignant and nonmalignant conditions, was first conceived more than 50 years ago, but problems associated with transplanting a ...

Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche. Journal of Experimental Medicine, 2021; 218 (3) DOI: 10.1084/jem.20192283; Cite This Page: MLA; APA; ...

More information: Shuhei Koide et al. Tracking clusterin expression in hematopoietic stem cells reveals their heterogeneous composition across the lifespan, Blood (2025). DOI: 10.1182/blood.2024025776 ...

Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis. Nature Communications , 2019; 10 (1) DOI: 10.1038/s41467-019-09028-w Cite ...

But that’s not all. The team could predict the function of the hematopoietic stem cells based on the activity of two growth factors that are also present in humans. The two growth factors – Kitl and ...

As with any complex system, hematopoietic stem cells lose functionality as they age - and, in the process, contribute to the risk of serious diseases, including blood cancers.

Nothing lives forever, but compared to other cells in the body, hematopoietic stem cells (HSCs) are remarkably long-lived. HSCs are blood-forming cells – they give rise to rapidly dividing ...

Hematopoietic stem cells often live in the bone marrow, which is a soft, spongy tissue in the center of most bones. These cells are also in a person’s blood.

Myeloablative allogeneic hematopoietic stem-cell transplantation is curative in children with sickle cell disease, but in adults the procedure is unduly toxic. Graft rejection and graft-versus-host ...