Co-localization of CD68, Col (1), and α-SMA in Liver Fibrosis. Col (1) is mainly derived from activated HSCs, whereas it is rarely reported to be secreted by CD68-positive cells.

Metabolic dysfunction-associated steatotic liver disease is prevalent among patients with chronic hepatitis B in Europe and ...

More information: Takao Seki et al, Intercellular communication between hepatic stellate cells and myofibroblasts mediated by osteopontin and FGF18 promotes liver fibrosis, iScience (2025). DOI ...

Liver scarring, or fibrosis, is a severe condition linked to chronic liver diseases. This scarring can worsen liver failure and cancer. Currently, there's no cure.

More information: Jiawang Tao et al, Lhx2 specifically expressed in HSCs promotes liver regeneration and inhibits liver fibrosis, Hepatology (2024). DOI: 10.1097/HEP.0000000000001201.

Adults with type 2 diabetes or obesity were more likely to have hepatic steatosis or clinically significant fibrosis than those with neither disease (P < .01 for both).Clinically significant ...

In the vast majority of cases, hepatic fibrosis is the result of chronic liver diseases, including viral hepatitis, alcoholic and nonalcoholic steatohepatitis, biliary diseases, ...

PPARβ/δ attenuates hepatic fibrosis by reducing SMAD3 phosphorylation and p300 levels via AMPK in hepatic stellate cells. Biomedicine & Pharmacotherapy, 2024; 179: 117303 DOI: ...

Researchers from Columbia University and the German Cancer Center have found that stellate cells—star-shaped liver cells long known as the main perpetrators of liver fibrosis—have a commanding ...

Treating the liver slices with HDAC6 inhibitors greatly reduced signs of fibrosis, showing that these compounds can stop – and possibly even reverse – the scarring process at the cellular level.

Of the 19 people with advanced stage 3-4 liver fibrosis, 84 per cent also had arthritis. However, of the 65 subjects without arthritis, only 5 per cent had advanced hepatic fibrosis.