ECM can directly influence the function of surrounding cells through interaction with cell surface receptors, including integrins and nonintegrin matrix receptors (such as discoidin domain ...

Non-parenchymal cells like hepatic stellate cells (HSCs), Kupffer cells ... Understanding their function is vital for new therapies. Exosomes are emerging as potential treatments for liver ...

This excessive deposition disrupts the normal liver architecture and function, contributing to ... in the Fibrogenic ...

In the liver, HepaStem cells exert a number of different effects: ‘cooling down’the proinflammatory environment of the diseased liver, inhibiting further hepatic stellate cell activation and ...

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...