Researchers have made a significant breakthrough in understanding how certain pathogens defend themselves against the host's immune ... signaling for their defense mechanisms.

See the article online for full details of the relationships. E.H. Sklan, P. Charuworn and P.S. Pang declared no competing interests. Viral life cycle and major host cell defense pathways.

However, Pnkp and Rnl1 repair the broken tRNAs and thereby thwart the host defense mechanism. Pnkp remodels the ends of the broken tRNA as follows: (i) it converts the 2’,3’-cyclic-PO 4 to a 3’-PO 4 ...

A novel innate host defense mechanism for subverting microbial pathogenesis has also been identified and is being translated into a prototypic form of therapy termed allosteric therapeutics. A ...

Throughout evolution, bacteria and phages have undergone an arms race in which phages infect bacteria, which in turn develop mechanisms to resist the attacks. Much of this defense is encoded in ...

An immunoblotting technique determined that the probe interacts with a specific receptor — a protein known as TREM2 — on ...

Deciphering the gut biome's, including helminths', influence on human trained immunity will unlock novel immunotherapies harnessing the immune reprogramming potential of their secreted factors and ...